Identification of metastasis and prognosis-associated genes for serous ovarian cancer
نویسندگان
چکیده
منابع مشابه
Identification of genes associated with ovarian cancer metastasis using microarray expression analysis.
Although the transition from early- to advanced-stage ovarian cancer is a critical determinant of survival, little is known about the molecular underpinnings of ovarian metastasis. We hypothesize that microarray analysis of global gene expression patterns in primary ovarian cancer and metastatic omental implants can identify genes that underlie the metastatic process in epithelial ovarian cance...
متن کاملAge is associated with prognosis in serous ovarian carcinoma
PURPOSE The survival duration of elderly patients with epithelial ovarian carcinoma is shorter than that of their younger counterparts. This variation in survival duration is likely attributed to differences in the distribution of histological type or grade, International Federation of Gynecology and Obstetrics (FIGO) staging, and undertreatment, but this observation remains controversial. This...
متن کاملMicroenvironment and Immunology CD73 Is Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer
The cell surface nucleotidase CD73 is an immunosuppressive enzyme involved in tumor progression and metastasis. Although preclinical studies suggest that CD73 can be targeted for cancer treatment, the clinical impact of CD73 in ovarian cancer remains unclear. In this study, we investigated the prognostic value of CD73 in high-grade serous (HGS) ovarian cancer using gene and protein expression a...
متن کاملIsolated Axillary Lymph Node Metastasis from Serous Ovarian Cancer
A 68-year-old female with past medical history of stage IIIc serous ovarian cancer after cytoreductive surgery and adjuvant chemotherapy came to clinic for regular follow-up visit. Physical examination was completely normal except for an isolated left axillary lymph node enlargement. Patient's abdominal sonogram and CT scan of abdomen and pelvis did not show any other new metastasis. Surgical e...
متن کاملSALL4 is a marker of poor prognosis in serous ovarian carcinoma promoting invasion and metastasis.
Spalt-like transcription factor 4 (SALL4) is a transcription factor which is able to regulate development and embryonic stem cell pluripotency, and it is also involved in some tumor progression. However, the role of SALL4 in serous ovarian carcinoma (SOC) is still controversial. In this study, we determined the SALL4 expression in ovarian carcinoma (OC) cell lines and SOC tissues, and explored ...
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ژورنال
عنوان ژورنال: Bioscience Reports
سال: 2020
ISSN: 0144-8463,1573-4935
DOI: 10.1042/bsr20194324